Efficacy and Safety of Fluoxetine in Children and Adolescents with Depression:A Meta-analysis / 医药导报
Herald of Medicine
;
(12): 239-243, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-700993
ABSTRACT
Objective To evaluate efficacy and safety of fluoxetine in comparison with placebo in children and adolescents with depression. Methods Randomized controlled trials (RCTs) on fluoxetine were searched in CBM,Wangfang, VIP,CNKI,PubMed,EMbase,Ovide and Cochrane Library from inception to October 2016 by computer.The pooled mean difference and relative risk were assessed by Meta analysis with RevMan 5.0 software. Results A total of 8 RCTs were included for the final analysis.Curative effect analysis showedin Children's Global Assessment Scale [MD= 3.91,95%CI(1.66,6.16),P= 0.0007] and Children's Depression Inventory [MD = -1.98,95%CI(-3.40,-0.57),P = 0.006],fluoxetine exerted a good effect in treating children's depression.Fluoxetine was equivalent to placebo in safety. Conclusion This study supports the conclusion that the benefits of fluoxetine in treating children and adolescents with depression are greater than the potential risk.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Etiology study
/
Systematic reviews
Language:
Chinese
Journal:
Herald of Medicine
Year:
2018
Type:
Article
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