Influence of Iguratimod on Systemic Lupus Erythematosus Mice / 医药导报

ABSTRACT

Objective To investigate the protective effects of iguratimod on systemic lupus erythematosus model mice. Methods A total of 30 female BALB/c mice were randomly divided into blank control group,model control group and igurati-mod drug intervention group,with 10 mice in each group.The blank control group was given saline by intraperitoneal injection in-tervention group.The model control group and iguratimod intervention group were given 0.5 mL of pristane, Then the drug inter-vention group began to be fed with iguratimod 6.5 mg·kg-1·d-1from the next day.After 7 months of feeding,the serum autoanti-body(anti nuclear antibody,anti ds-DNA antibody,anti RNP/sm antibody),the level of urine protein,serum urea nitrogen and serum creatinine,as well as the renal pathological changes of the three groups were detected and compared. Results Serum an-ti nuclear antibody,anti ds-DNA antibody and anti RNP/sm antibody levels of the drug intervention group were significantly lower than those of the model control group (P<0.05);Positive rate of urine protein,serum urea nitrogen,serum creatinine of the drug intervention group were significantly lower than those of the model control group(P<0.05).while the renal pathological change of this group is not obvious. Conclusion Iguratimod can inhibit the occurrence of serum antibody in a certain extent,improve the urine protein,serum urea and serum creatinine level of mouse model with systemic lupus erythematosus,which has protective effects on systemic lupus erythematosus.