Association of arsenic exposure through drinking water and tumor:a meta-analysis / 中华地方病学杂志

ABSTRACT

Objective To systematically review the relationship between arsenic exposure through drinking water and human cancer risk.Methods China National Knowledge Infrastructure(CNKI), VIP Database, WanFang Data,China Biology Medicine Disc(CBM),PubMed,Embase and Cochrane Library were searched through computer to find out the relationship between arsenic exposure and tumorigenesis.The search period was from January 1,1997 to January 1,2017.Meta-analysis was performed using RevMan 5.3.The heterogeneity of the literatures that met the inclusion criteria was examined,and analysis was performed by using fixed effect model or random effect model. OR and 95%CI were calculated, the publication bias was evaluated by inverted funnel plot, and sensitivity analysis was performed. Results Totally 14 literatures entered into this study, 13 927 people in arsenic exposure group, 5 720 people in control group. The meta-analysis showed that, 14 literatures were homogeneous through the heterogeneity test, and was analyzed in the fixed effect model with OR (95 % CI) = 1.20 (1.09, 1.33),which suggested that the risk of cancer in the arsenic exposure group was 1.20 times higher than that in control group. Inverted funnel plot was basically symmetrical,literatures publication bias was small;the result was more reliable by sensitivity analysis.Conclusion Arsenic exposure through drinking water may be a risk factor of tumor.