Establishment of reference values for analysis of thyroid function in school-age children in iodine-adequate nutrition areas / 中华地方病学杂志

ABSTRACT

Objective To establish reference values for thyroid hormone in school-age children in iodineadequate nutrition areas.Methods Totally 128 8-10-year-old healthy children (male62,female66) were screened rigorously in iodine-adequate nutrition areas (median of urinary iodine100-200 μg/L).The values of total triiodothyronine (TT3) total thyroxine (TT4) free triiodothyronine (FT3),free thyroxine (FT4),thyrotropin (TSH）,thyroglobulin (Tg),thyroid peroxidase antibody (TPOAb),and thyroglobulin antibody (TgA) in serum were determined through the Access 2 Immunoassay System (Beckman-Coulter,USA) using a chemiluminescence detection system.Results Normal reference ranges for thyroid function indicators in children (95％ confidence limit) of TT3,TT4,FT3,FT4,TSH,and Tg were 1.63-3.36 nmol/L,110.65-186.67 nmol/L,4.65-7.25 pmol/L,9.75-15.59 pmol/L,1.10-5.54 mU/L,and 3.75-36.27 μg/L,respectively.There was no significant difference in hormone levels between boys and girls (P ＞ 0.05).The thyroid function indices were substantially different between children and adults.Conclusions Normal reference range of thyroid function index of children is different from that of adults.It is necessary to establish the reference range of thyroid function indices for children in order to diagnose thyroid diseases and monitor iodine nutrition.