Progress in the effects of arsenic on glutaredoxin system / 中华地方病学杂志

ABSTRACT

The glutaredoxin system (Grxs) is one of the important antioxidant systems,including glutaredoxin,glutathione,glutaredoxin reductase and nicotinamide adenine dinucleotide phosphate.Glutaredoxin is a small protein as oxidoreductases with the function of deglutathionylation,reducing antioxidants and recombination of iron-sulfur enzymes.In studies of ceils,animals and plants,arsenic and its metabolites can induce reactive oxygen species,generate free radicals and trigger oxidative stress.The Grxs plays an essential role of antioxidant and maintains redox state in arsenic poisoning.Therefore,the article reviewed the anti-oxidation effect of Grxs in arsenic poisoning.