The role and research progress of Wnt/β-catenin signal pathway in the pathogenesis of osteoarthritis or Kashin-Beck disease / 中华地方病学杂志

ABSTRACT

Osteoarthritis is a chronic,degenerative joint disease characterized by destruction of articular cartilage,osteophyte formation and narrowing of the joint space,which seriously affects the life quality of patients.However,the pathogenesis of osteoarthritis is still not clear.Kashin-Beck disease (KBD) is an endemic,chronic and deformative osteoarthropathy that mainly occurs in children aged 5-15 years old.The etiology and pathogenesis of KBD are still unclear.Wnt/β-catenin signaling pathway is involved in the development of embryonic cartilage and maintaining the stability of adult bones,which is a key pathway regulating the growth,development and differentiation of chondrocytes.Therefore,the authors review the progress of Wnt/β-catenin signaling pathway in the pathogenesis of osteoarthritis or KBD.