Difference in detection results and antimicrobial resistance of multidrug-resistant organisms in intensive care unit and non-intensive care unit / 中国感染控制杂志

ABSTRACT

Objective To understand detection results and difference in multidrug-resistant organisms(MDROs) in intensive care unit(ICU)and non-ICU.Methods Strains isolated from clinical specimens of hospitalized patients in a hospital from January 2015 to December 2016 were analyzed, 6 kinds of MDROs were conducted targeted monitoring, isolation and antimicrobial resistance of 6 kinds of MDROs from ICU and non-ICU patients were compared. Results A total of 1 013 strains of 6 kinds of MDROs were monitored, isolation rate was13.13％.Isolation rate of MDROs in ICU was higher than that of non-ICU (24.60％vs 5.47％, P＜0.001).Carbapenem-resistant Acinetobacter baumannii(CRAB)was the main isolated MDROs, accounting for 69.40％;of different pathogenic organisms, isolation rate of CRAB was the highest(55.75％).The main MDROs detected in ICU and non-ICU were both CRAB, accounting for 76.32％and 48.62％respectively;Of isolated pathogens, isolation rate of MDROs in ICU was higher than that of non-ICU(47.95％vs 8.02％, P＜0.001).Antimicrobial resistance rates of Escherichia coli isolated from ICU to ticarcillin/clavulanic acid, ceftriaxone, cefotaxime, cefepime, imipenem, meropenem, amikacin, and gentamicin were all higher than that of non-ICU, resistant to piperacillin was lower than non-ICU, difference was statistically significant(all P≤0.05);resistance rates of Klebsiella pneumoniae from ICU to common antimicrobial agents(except piperacillin)were all higher than non-ICU(all P＜0.05).Resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa from ICU to common antimicrobial agents were all higher than non-ICU (all P＜0.05).Resistance rates of Staphylococcus aureus isolated from ICU to oxacillin, ciprofloxacin, tetracycline, and rifampicin were all higher than non-ICU (all P＜0.05), and resistance rates of Enterococcus faeciumto quinupristin/dafoeleptin and tetracycline were both lower than non-ICU (both P＜0.05).Conclusion Isolation rate of MDROs in ICU is high, resistance rates to most antimicrobial agents are also higher than non-ICU, monitoring on MDROs in ICU should be strengthened, and according prevention and control measures should be formulated.