Clinical effect of ozagrel and edaravone in the treatment of cerebral ischemic stroke / 中国基层医药

ABSTRACT

Objective To investigate the clinical curative effect of ozagrel and edaravone in the treatment of cerebral ischemic stroke.Methods 100 patients with cerebral ischemic stroke were chosen to research,and they were divided into control group and research group,50 cases in each group.The control group was treated with ozagrel,the research group was treated with edaravone on the basis of control group.The activities of daily living scale(ADL index score) and the Scandinavian Stroke Scale(SSS score) before treatment,7 d and 14 d after treatment were observered,and the clinical curative effect between the two group was compared.Results The total effective rate of the research group was higher than that of the control group (92.00％ vs,72.00％),the difference was statistically significant (x2 =6.775,P ＜0.05).There was no statistically significant difference in SSS score between the two groups before treatment (t =0.159,P ＞ 0.05).After treatment,the SSS score were significantly reduced compared with before treatment,the differences were statistically significant (t =4.552,10.023,0.616,4.854,all P ＜ 0.05).At 7d and 14d after treatment,the SSS score of the research group was lower than that of the control group,the difference was statistically significant (t =4.055,5.017,all P ＜ 0.05).There was no statistically significant difference in ADL index between the two groups before treatment (t =0.059,P ＞ 0.05).After treatment,the ADL index were significantly higher compared with before treatment,the differences were statistically significant (t =7.657,22.209,5.453,12.832,all P ＜ 0.05).At 7d and 14d after treatment,the ADL index score of the research group was higher than that of the control group,the difference was statistically significant (t =2.559,9.356,all P ＜ 0.05).Conclusion Ozagrel combined with edaravone is advantageous to the recovery of neural function of patients with cerebral ischemic stroke,promote the improvement of activities of adily living,with good clinical curative effect.