Effect of ventolin combined with pulmicort in the treatment of children with asthma and its influence on inflammatory cytokines / 中国基层医药

ABSTRACT

Objective To study the effect of ventolin combined with pulmicort in the treatment of children with asthma and its influence on inflammatory cytokines .Methods 100 children with asthma were randomly divided into observation group(50 cases) and control group(50 cases) according to the digital table.The control group was given pulmicort treatment ,the observation group was given 0.5％ ventolin combined with pulmicort .The course of treatment was 3-5 days.The remission time,the levels of inflammatory cytokines (IL-17 and TGF ) and adverse reactions were compared between the two groups .Results After treatment,the VC,FVC and PEFC of the observation group were significantly better than those of the control group ,the differences were statistically significant (t=2.412, 9.806,3.922,all P<0.05).The remission time of clinical symptoms of the observation group was better than those of the control group(t=5.182,4.576,4.166,5.761,all P<0.05 ).There was no statistically significant difference in the side effects between the two groups (18.00％vs.16.00％,χ2 =2.153,P>0.05).The levels of IL-6 and TGF in the observation group were lower than those in the control group (t =8.234,25.075,all P <0.05). Conclusion Ventolin combined with pulmicort in the treatment of children with asthma can effectively relieve clinical symptoms,reduce the inflammatory cytokines ,improve pulmonary function ,so it is worthy of further clinical application .