Observation of tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea with facial hormone dependent dermatitis / 中国基层医药

ABSTRACT

Objective To observe the efficacy and safety of tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea with facial hormone dependent dermatitis .Methods A total of 80 cases with rosacea complicated with facial hormone dependent dermatitis were selected , and they were randomly divided into observation group and control group according to the digital table ,40 cases in each group .The observation group was treated with 0.1％ tacrolimus ointment besmear outside 2 times a day,a total of eight weeks,and at the same time,ornidazole and clarithromycin was taken orally for 4 weeks.The control group was treated with 0.1％tacrolimus ointment besmear outside 2 times a day for a total of eight weeks .The curative effects of two groups after treatment,and the symptom rebound rates aftre 4 weeks of treatment were compared .Results The total effective rate of the observation group was 92.5％,which of the control group was 67.5％,the difference between the two groups was statistically significant(χ2 =7.68,P<0.05).The symptom scores before treatment between the two groups had no statistically significant difference[(19.93 ±0.76)points vs.(19.89 ±4.07)points,P>0.05].After treatment, the symptom scors between the two groups had statistically significant difference (P<0.05).The bounce rate of the observation group was 7.5％,which of the control group was 31.58％.The difference between the two groups was statistically significant(χ2 =5.97,P<0.05).Conclusion 0.1％tacrolimus ointment combined with ornidazole and clarithromycin in the treatment of rosacea complicated with hormone-dependent facial dermatitis has satisfied curative effect and security ,the comprehensive treatment is better than single treatment .