Application effect of dexmedetomidine combined with oxycodone in traditional lysis method of shoulder joint adhesions / 中国基层医药

ABSTRACT

Objective To observe the effect of dexmedetomidine ( Dex ) combined with oxycodone in the traditional lysis method of shoulder joint adhesions .Methods Sixty patients with shoulder joint adhesions in ASA Ⅰor Ⅱby the traditional lysis method were selected ,and they were randomly divided into control group and observation group,30 cases in each group.The control group was administered with Dex1.0μg/kg +fentanyl 1μg/kg.The observation group was administered with Dex1.0μg/kg+oxycodone 0.10mg/kg.The VAS scores and postoperative adverse reactions were compared .Results The VAS score of each group decreased with the prolong of postoperative analgesia time.The VAS scores in the observation group at postoperative 1h,4h,8h[(3.00 ±0.54)points,(1.98 ± 0.56)points,(1.55 ±0.36) points] were lower than those in the control group [(3.91 ±0.33) points,(2.88 ± 0.66)points,(2.26 ±0.77)points],the differences were statistically significant (t =3.42,4.11,2.43,all P <0.05).There was no statistically significant difference in VAS score between the two groups at postoperative 12h(P>0.05).The incidence rates of adverse reactions of respiratory depression ,tachycardia,intraoperative awareness in the control group were 26.7％(8/30),50.0％(15/30),13.3％(4/30),respectively,which in the observation group were 6.7％(2/30),20.0％(6/30),0.0(0/30),respectively,the differences were statistically significant between the two groups(χ2 =4.320,5.934,5.333,all P<0.05).Conclusion Dex combined with oxycodone can ensure good sedation and forgetting effect ,and the incidence rate of adverse reactions is low .