Analysis of the effect of amiodarone combined with carvedilol in the treatment of arrhythmia / 中国基层医药

ABSTRACT

Objective To explore the effect of amiodarone combined with carvedilol in the treatment of patients with arrhythmia.Methods 90 patients with cardiac arrhythmia were selected .According to different treatment,the patients were divided into control group and observation group ,45 cases in each group.The control group was treated with amiodarone , the observation group was given amiodarone combined with carvedilol .The therapeutic effect of the two groups was observed .Results Before treatment , the systolic blood pressure [ ( 149 ± 11)mmHg vs.(151 ±14) mmHg)],diastolic blood pressure [(95 ±11) mmHg vs.(95 ±12) mmHg)],heart rate [(143 ±16)times/min vs.(141 ±18)times/min] between the two groups had no statistically significant differences (t =6.214, 1.907, 3.228, all P >0.05 ).After treatment, the effective rate ( 91.11％), cardioversion rate (88.89％),standard time to achieve effective treatment [(2.50 ±0.79) d],systolic blood pressure [(119 ± 12)mmHg],diastolic blood pressure[(78 ±12)mmHg],heart rate [(78 ±20)times/min] in the observation group were better than those in the control group [86.67％,75.56％,(5.62 ±3.16) d,(142 ±15) mmHg,(90 ± 13)mmHg,(99 ±23) times/min],and the differences between the two groups were statistically significant (χ2 =8.235,7.157,t =6.214,5.718,5.102,all P<0.05).Conclusion Carvedilol combined with amiodarone in the treatment of patients with abnormal heart rate can significantly improve the cardiac function ,suppress deterioration , and can be widely used in clinical treatment .