Analysis of therapeutic effect of sodium hyaluronate intra-articular injection combined with oral Yanghe decoction in the treatment of knee osteoarthritis / 中国基层医药

ABSTRACT

Objective To investigate the curative effect of sodium hyaluronate intraperitoneal injection combined with oral Yanghe decoction in the treatment of knee osteoarthritis .Methods 80 patients with knee osteoar-thritis were randomly divided into two groups ,40 cases in each group .The control group was given intra -articular injection of sodium hyaluronate ,and the study group was treated with Yanghe decoction in addition .The TCM symptom score , knee joint index , overall treatment effect and quality of life were compared between the two groups .Results The total score of TCM symptoms after treatment in the study group was (7.08 ±1.18)points,which was significantly lower than (10.42 ±2.01)points in the control group(t=9.063,P<0.01).The VAS score and WOMAC score after treatment in the study group were (1.48 ±0.59)points,(19.10 ±3.08)points,respectively,which were significantly lower than (3.70 ±1.12)points and (23.40 ±3.56)points in the control group (t=11.091,5.777,all P<0.01). The HSS score after treatment in the study group was (83.04 ±10.49) points,which was significantly higher than (71.81 ±9.67)points in the control group(t =4.978,P<0.01).The physiological function,physical function, physical pain,mental health and energy scores after 6 months treatment in the study group were significantly higher than those in the control group (t=5.190,8.535,4.569,3.266,6.694,all P<0.01).The effective rate and total effective rate of the study group were 72.5％and 95.0％,respectively,which were significantly higher than those of the control group(50.0％,77.5％),the differences were statistically significant (χ2 =4.266,5.165,all P<0.05). Conclusion Sodium hyaluronate injection combined with oral Yanghe decoction is effective in the treatment of knee osteoarthritis.