Clinical effect of atorvastatin combined with aspirin in the treatment of acute cerebral infarction / 中国基层医药

ABSTRACT

Objective To investigate the clinical effect of atorvastatin combined with aspirin in the treatment of acute cerebral infarction ( ACI) .Methods 700 patients with ACI were selected ,and they were randomly divided into two groups according to the digital table ,with 350cases in each group.The control group was treated with aspirin .The observation group was given atorvastatin combined with aspirin .The neurological deficits ,daily living ability,overall treatment effect , disease related parameters and adverse reactions were compared between the two groups .Results After treatment,the NIHSS score,carotid IMT,plaque area,RI,TC,TG,LDL-C,hs-CRP,oxLDL,MDA,TNF-α, IL-6 and IL -1 levels in the observation group were (11.20 ±3.87) points,(1.04 ±0.13) mm,(0.51 ± 0.07)cm2,(63.26 ±2.56)%,(4.21 ±0.27)mmol/L,(1.32 ±0.12)mmol/L,(1.51 ±0.20)mmol/L,(1.61 ± 0.50)mg/L,(42.50 ±7.15) mg/L,(4.33 ±1.34)μmol/L,(419.65 ±51.16)μg/L,(120.04 ±22.50) ng/L, (310.45 ±44.82) ng/L,respectively,which were significantly lower than those in the control group [(14.79 ± 3.64)points,(1.20 ±0.17) mm,(0.67 ±0.12) cm2,(65.38 ±2.70)%,(4.76 ±0.36) mmol/L,(1.75 ± 0.17)mmol/L,(1.92 ±0.27) mmol/L,(2.32 ±0.67) mg/L,(60.15 ±9.15) mg/L,(6.19 ±1.40)μmol/L, (480.62 ±55.96)μg/L,(157.33 ±25.79)ng/L,(357.39 ±46.20)ng/L].The Barthel index,carotid artery lumen diameter,SV,DV,HDL-C and SOD levels in the observation group were (75.40 ±7.96),(7.57 ±0.24)mm, (0.789 ±0.18)m/s,(0.314 ±0.030)m/s,(1.69 ±0.15)mmol/L,(122.64±19.55)U/mL,respectively,which were significantly higher than those in the control group [(67.27 ±7.55),(7.23 ±0.28)mm,(0.673 ±0.125)m/s, (0.226 ±0.029)m/s,(1.42 ±0.20)mmol/L,(103.60 ±16.68)U/mL].The obvious effective rate and total effective rate of the observation group were 56.00% and 80.57%,respectively,which were significantly higher than those of the control group (39.71%and 68.00%,χ2 =18.599,14.478,all P<0.01).Conclusion Atorvastatin combined with aspirin in the treatment of patients with ACI has significant clinical effect and high safety .