The Role of Laryngopharyngeal Reflux as a Risk Factor in Laryngeal Cancer: A Preliminary Report
Clinical and Experimental Otorhinolaryngology
;
: 101-104, 2011.
Article
in English
| WPRIM
| ID: wpr-70191
ABSTRACT
OBJECTIVES:
To evaluate the significance of laryngopharyngeal reflux (LPR) as a risk factor in laryngeal cancer.METHODS:
We performed a case-control study with 29 consecutive laryngeal cancer patients who had undergone 24-hour ambulatory double pH monitoring from 2003 to 2006. The control group included 300 patients who had undergone 24-hour ambulatory double pH monitoring due to LPR-related symptoms. We analyzed the prevalence of LPR and numerous parameters from the 24-hour ambulatory double pH monitoring in the laryngeal cancer patient and control groups. Pathologic LPR is defined when more than three episodes of LPR occur in 24 hours.RESULTS:
The prevalence of pathologic LPR was significantly higher in the laryngeal cancer group than the control group (P=0.049). The reflux number of the upper probe was significantly higher in the laryngeal cancer group (P<0.001). However the effects of pathologic LPR on laryngeal cancer risk were diluted after adjusting for smoking and alcohol consumption in the multivariable logistic regression.CONCLUSION:
The pathologic LPR might be a possible risk factor in the development of laryngeal cancer. A further study should be necessary to verify the exact role of LPR in laryngeal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Alcohol Drinking
/
Smoking
/
Gastroesophageal Reflux
/
Case-Control Studies
/
Laryngeal Neoplasms
/
Prevalence
/
Risk Factors
/
Laryngopharyngeal Reflux
/
Hydrogen-Ion Concentration
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Clinical and Experimental Otorhinolaryngology
Year:
2011
Type:
Article
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