Effect of inhalation of budesonide combined with ambroxol hydrochloride in the treatment of acute exacerbation of chronic obstructive pulmonary disease / 中国基层医药

ABSTRACT

Objective To investigate the effect of inhalation of budesonide combined with ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease ( COPD ) in acute exacerbation stage . Methods 60 patients with acute exacerbation of COPD treated in the Department of respiratory medicine of Zhenhai People's Hospital from January 2013 to December 2015 were selected as the research subjects in Ningbo , and they were randomly divided into control group and observation group according to the digital table ,with 30 cases in each group.The control group received routine treatment, the observation group was given budesonide and ambroxol hydrochloride inhalation on the basis of conventional therapy .After 1 week of treatment ,the clinical efficacy indicators of pulmonary function,arterial blood gas analysis index,time of symptoms were compared between the two groups . Results The total effective rate of the observation group was 100.0％,which was higher than 83.3％of the control group (χ2 =5.455,P<0.05).After treatment,the forced expiratory volume in one second (FEV1),the ratio of FEV1 and forced vital capacity (FVC) (FEV1/FVC),arterial partial pressure of carbon dioxide (PaCO2),arterial oxygen pressure (PaO2) in the observation group were (2.09 ±0.69)L,(58.94 ±15.67)％,(35.08 ±3.79)mmHg, (85.92 ±4.97)mmHg,respectively,which in the control group were (1.43 ±0.57)L,(43.12 ±11.03)％,(48.47 ± 4.24)mmHg,(79.54 ±4.56)mmHg,respectively,the differences between the two groups were statistically significant (t=4.039,4.522,12.896,5.181,all P<0.05).The remission time of shortness of breath ,cough,expectoration in the observation group were (2.04 ±0.86)d,(4.49 ±1.25)d,(4.56 ±1.34)d,respectively,which were shorter than those in the control group [(3.36 ±1.08)d,(6.53 ±1.82)d,(6.78 ±1.91)d],the differences between the twogroups were statistically significant (t=5.237,5.061,5.212,all P<0.05).Conclusion Inhalation of budesonide combined with ambroxol hydrochloride in the treatment of acute exacerbation of COPD can effectively improve the treatment effect , and the pulmonary ventilation function and arterial blood gas status , and shorten the time of remission,and is benefit to disease control .