Study on the correlation between serum IL-17 level and sleep-emotion disorder in type 2 diabetes mellitus patients complicated with peripheral neuropathy / 中国基层医药

ABSTRACT

Objective To evaluate the sleep and mood of patients with type 2 diabetes and peripheral neuropathy , and to explore whether the results were related to the level of interleukin-17 ( IL -17 ) . Methods 130 cases of type 2 diabetes diagnosed in Department of Endocrinology , First Affiliated Hospital of Medical University of Anhui from September 2015 to July 2016 were selected ,46 diabetes mellitus patients without peripheral neuropathy ( NDPN group ) and 84 patients with peripheral neuropathy ( DPN group ) were selected in the study.According to Toronto score (TCSS),DPN patients were divided into mild DPN group (DPN1 group,54 cases), medium and severe DPN group (DPN2 group,30 cases).The severity of insomnia and depressive symptoms were assessed by Pittsburgh Sleep Quality Index (PSQI) and 17-term Hamilton's Depression Scale (HAMD-17).The serum levels of IL-17 were measured .Results The scores of PSQI and HAMD-17 in the DPN group were signifi-cantly higher than those in the NDPN group,The score was (9.74 ±2.87),(10.85 ±2.20),and (12.03 ±2.71)respectively,the differences was statistically significant ( F =7.43, P =0.001 ), and the scores of PSQI and HAMD-17 in the DPN2 group were significantly higher than those in the DPN 1 group,the scores were (6.80 ± 2.74),(7.52 ±2.49),and (8.97 ±3.22) respectively,the differences was statistically significant (F=5.73,P=0.004 ) .The level of IL-17 in the DPN group was significantly higher than that in the NDPN group ,the differences was statistically significant(F=5.27,P=0.006).There was no statistically significant difference in IL -17 between the DPN1 group and the DPN2 group.IL-17 level of patients with PSQI >10 was significantly higher than that of patients with PSQI≤10 (t=5.52,P=0.021).The level of IL-17 in patients with HAMD-17≥7 and patients with HAMD-17 <7 had no statisticallysignificant difference .Conclusion Sleep and mood is closely related to the condition of patients with type 2 diabetes and peripheral neuropathy .Sleep condition may affect the level of IL -17 and the development of neuropathy .