Clinical effect of zinc gluconate combined with tetralogy of viable bifidobacterium tablets in the treatment of infantile autumn diarrhea / 中国基层医药

ABSTRACT

Objective To study the clinical effect of zinc gluconate combined with tetralogy of viable bifidobacterium tablets in the treatment of infantile autumn diarrhea .Methods 76 children with diarrhea in Lishui Hospital of Traditional Chinese Medicine from September to November in 2014 and from September to November in 2015 were selected as research subjects .All patients were randomly divided into control group ( n=38 ) and observa-tion group(n=38) by registration order.The control group was given tetralogy of viable bifidobacterium tablets ,while the observation group was given zinc gluconate combined with tetralogy of viable bifidobacterium tablets .The disappea-ring time of disease and the clinical symptoms after treatment for 72 h were compared between the two groups . Results The disappearing time of fever in the observation groupwas (28.81 ±5.72) h,which in the control group was (41.67 ±7.91)h,the difference was statistically significant between the two groups (t=10.358,P=0.011).The disappearing time of abdominal distension in the observation group was (40.28 ±7.96)h,which in the control group was (52.35 ±11.54)h,the difference was statistically significant between the two groups (t=7.334,P=0.021).The disappearing time of emesis in the observation groupwas (35.71 ±10.37)h,which in the control group was (50.66 ± 12.89)h,the difference was statistically significant between the two groups (t=9.214,P=0.017).The total effective rate of the observation group was 97.37％,which was higher than 81.58％ of the control group (χ2 =15.240,P<0.05 ) .In addition ,no complication was observed during the treatment .Conclusion The combination therapy of zinc gluconate and tetralogy of viable bifidobacterium tablets for infantile autumn diarrhea has high efficacy ,less adverse reaction,short therapy time ,and it has clinical value .