Effect of atorvastatin calcium on carotid atherosclerotic plaque in patients with cerebral infarction / 中国基层医药

ABSTRACT

Objective To investigate the clinical effect of atorvastatin calcium on carotid artery plaque in patients with cerebral infarction.Methods From January 2016 to September 2017,100 patients with cerebral infarction in the Second People's Hospital of Yuyao were selected.According to random number table method,the patients were randomly divided into observation group and control group,with 50 cases in each group.The control group was treated by intravenous injection of ginkgo leaf extract and dipyridamole injection.The observation group was treated by intravenous injection of ginkgo leaf extract and dipyridamole injection combined wth atorvastatin calcium therapy.The clinical effects and changes of blood indicators were compared between the two groups.Results Before treatment,the IMT thickness,plaque thickness,blood flow velocity,TG,TC,LDL-C,HDL-C,plasma viscosity,erythrocyte aggregation index,erythrocyte volume,fibrinogen and erythrocyte sedimentation rate (ESR) between the two groups had no statistically significant differences (all P ＞ 0.05).After treatment,the IMT thickness,plaque thickness,blood flow velocity,TG,TC,LDL-C,HDL-C,plasma viscosity,erythrocyte aggregation index and hematocrit,fibrinogen,ESR and total effective rate in the observation group were significantly better than those in the control group,and the differences between the two groups were statistically significant(t =5.012,6.225,8.147,6.225,5.110,6.021,5.002,5.012,6.002,5.102,5.042,6.053,x2 =8.125,all P ＜ 0.05).Conclusion Atorvastatin calcium tablets combined with intravenous injection of ginkgo leaf extract and dipyridamole in the treatment of atherosclerotic cerebral infarction can effectively improve blood rheological parameters and blood lipid parameters,and the treatment effect is better than ginkgo leaf extract and dipyridamole.