Curative effect of warfarin therapy on atrial fibrillation complicated with cerebral embolism and its influence on D-dimer / 中国基层医药

ABSTRACT

Objective To observe the clinical curative effect of warfarin therapy on atrial fibrillation complicated with cerebral embolism,and its influence on D－dimer.Methods From January 2013 to March 2016,80 cases of atrial fibrillation complicated with cerebral embolism in Shanxi Cardiovascular Disease Hospital were selected in the study.By using the random number table method,the patients were divided into two groups,with 40 cases in each group.The control group was given aspirin therapy,the observation group was given warfarin treatment.The treatment effect,D －dimer level,blood coagulation function index,cerebral embolism recurrence rate and mortality were compared between the two groups.Results The total effective rate of the observation group was 95.0%,which of the control group was 90.0%,there was no statistically significant difference between the two groups (χ2＝0.721,P＞0.721).After treatment,the D－dimer,prothrombin time (PT),activated partial clotting enzyme live time (APTT), thrombin time (TT)in the observation group were (162.85 ±60.53)μg/L,(20.54 ±4.03)s,(42.84 ±8.47 )s, (22.59 ±4.84)s,respectively,which in the control group 1were (245.41±83.24)μg/L,(16.39 ±3.41)s,(34.23 ± 7.59 )s,(17.98 ±4.27 )s,respectively,the differences between the two groups were statistically significant (t ＝5.073,4.972,4.788,4.972,all P ＜0.05 ).The recurrence rate of cerebral embolism in the observation group (7.5%)was significantly lower than that in the control group (25.0%)(χ2＝4.501,P＜0.05 ).The mortality of the observation group (2.5%)was slightly lower than that of the control group (5.0%),but there was no statistically significant difference (χ2＝0.346,P＞0.346).Conclusion Warfarin therapy in the treatment of atrial fibrillation complicated with cerebral embolism has significant clinical effect,it has anticoagulant effect,and can reduce the D－dimer level,improve patients'anticoagulant function,effectively prevent the cerebral embolism happen again,and improve the prognosis.