Clinical study of benazepril combined with amlodipine in the treatment of essential hypertension / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of benazepril combined with amlodipine in the treatment of essential hypertension.Methods From January 2016 to January 2017,90 patients with coronary heart disease in Taizhou Central Hospital were selected in the study,and they were randomly divided into three groups,with 30 cases in each group.The observation group(A group)was treated with benazepril combined with amlodipine,the control group (B group )was treated with benazepril,and the control group (C group)was treated with amlodipine. The clinical efficacy,blood pressure,blood lipid changes,blood glucose changes before and after treatment in the three groups were compared.Results The total effective rate of A group was 96.367%,which of B group was 66.67%, which of C group was 70.00%,and the clinical efficacy among the three groups had statistically significant difference (χ2＝11.96,P＜0.05).Before treatment,the systolic blood pressure(SBP)and diastolic blood pressure(DBP)of the three groups had no statistically significant differences(F＝0.98,0.85,all P＞0.05).After treatment,the SBP, DBP of the three groups were significantly lower than those before treatment(t＝5.68,7.21,3.52,3.16,3.64,3.16, all P＜0.05),the SBP and DBP of A group were significantly lower than those of B group and C group(F＝6.24, 3.27,all P＜0.05).After treatment,only the TC,TG,HDL－C levels of A group had statistically significant differ-ences compared with those before treatment(t＝5.29,6.28,2.31,all P＜0.05),and the TC,TG levels of A group were significantly lower than those of B group and C group(F＝3.18,2.86,all P＜0.05),while the HDL－C level of A group increased significantly compared with that of B group and C group(F＝3.78,P＜0.05 ).Before treatment, the FPG,FINS among the three groups had no statistically significant differences (F＝0.85,0.95,all P＞0.05 ). After treatment,only the FPG,FINS of A group had statistically significant differences compared with those before treatment(t＝5.14,3.65,all P＜0.05),and the FPG,FINS of A group were significantly lower than those of B group and C group(F＝5.27,2.86,all P＜0.05).The adverse reaction rate in A group was 6.67%,which in B group was 30.00%,which in group C was 26.67%,and there was no statistically significant difference among the three groups (χ2＝1.72,P＞0.05).Conclusion Benazepril combined with amlodipine in the treatment of essential hypertension is effective,safe,and has less adverse reactions.