Effects of general anesthesia combined with epidural anesthesia on oxidative stress in patients with cervical cancer after laparoscopic hysterectomy / 中国基层医药

ABSTRACT

Objective To investigate the application value of general anesthesia combined with epidural anesthesia in patients with cervical cancer after laparoscopic hysterectomy.Methods From January 2014 to November 2016,64 patients with cervical cancer in Beijing Ditan Hospital were selected and randomly divided into control group and study group,with 32 cases in each group.Both two groups were treated with laparoscopic hysterectomy,and the control group was treated with general anesthesia,the study group was treated with general anesthesia combined with epidural anesthesia.The amount of general anesthesia,the time of surgery and postoperative recovery time,the incidence of adverse reactions,preoperative and postoperative oxidative stress－related indicators[metabolic enzyme monoammine oxidase A (MAOA),enzyme tyrosine hydroxylase (TH),glutathione peroxidase (GSH－Px),5 －hydroxytryptamine (5 －HT)]were statistically compared between the two groups.Results The operative time,postoperative recovery time and doage of atracurium,remifentanil,propofol in the study group were less than those in the control group (t＝6.928,11.205,16.966,7.798,16.839,all P＜0.01).There were no statistically significant differences in the MAOA,TH,GSH－Px and 5 －HT levels between the two groups before treatment (all P＞0.05),but after operation, the MAOA,TH and 5 －HT levels in the study group were significantly lower than those in the control group,the GSH－Px level was significantly higher than that of the control group,the differences were statistically significant (t＝28.585,26.346,10.850,21.827,all P＜0.01).The incidence rates of cardiac tachycardia[18.75%(6/32)],vomiting and nausea[15.63%(5/32)],and restless[9.38%(3/32)]in the study group were lower than those in the control group[43.75%(14/32),37.50%(12/32),40.63%(13/32)],the differences were statistically significant (χ2＝4.655,3.925,8.333,all P＜0.05).Conclusion General hysterectomy combined with epidural anesthesia in patients with cervical cancer after laparoscopic hysterectomy can effectively reduce the postoperative oxidative stress,reduce the dosage of narcotic drugs and the time of operation and wake up,and the incidence rate of adverse reactions is low.