Clinical efficacy of modified cistanche decoction combined with lactulose oral liquid in the treatment of constipated irritable bowel syndrome and its impact on quality of life / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of modified cistanche decoction combined with lactulose oral liquid in the treatment of patients with constipation -type irritable bowel syndrome ,and to observe its effect on improving the quality of life of patients.Methods From June 2013 to June 2016,the clinical diagnosis and treatment of 76 patients with constipation-predominant irritable bowel syndrome in the People's Hospital of Qingyuan County were retrospectively analyzed.Among them,lactulose oral liquid was used in the control group.On the basis of the control group,cistanche soup was given in the treatment group ,the control group and the treatment group had 38 cases.The clinical effects,adverse reactions were analyzed ,and before and after treatment ,TCM syndrome score and quality of life score were recorded.Results After treatment,the TCM syndrome scores of the treatment group were significantly lower than those of the control group (t＝2.87,3.17,2.68,3.75,4.27,3.83,5.02,4.40,2.48, P＝0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.01),the quality of life dimensions scores of the treatment group were significantly higher than those of the control group (t＝3.10,3.44,3.36,3.58,4.51,3.32,2.95,2.89, P＝0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00).However,after treatment,the scores of TCM syndromes in both two groups were significantly lower than those before treatment ( control groupt ＝4.28,5.11,4.07,6.38,5.06, 2.11,7.32,4.38,20.22,P＝0.00,0.00,0.00,0.00,0.00,0.00,0.04,0.00,0.00;treatment groupt ＝7.81, 9.86,7.68,13.76,9.31,6.57,14.639.62,7.36,P＝0.00,0.00,0.00,0.00).The scores of all dimensions of life quality were significantly higher than those before treatment (control groupt＝2.85,3.59,2.58,2.60,4.01,4.88, 3.05,2.36,P＝0.00,0.00,0.01,0.01,0.00,0.00,0.00,0.02;treatment groupt＝5.57,6.72,6.60,6.40,7.74, 7.63,5.84,6.30,P＝0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00).The total effective rate of the treatment group was 86.84%,which was significantly higher than 65.79% of the control group(χ2＝7.13,P＝0.02).There were no significant adverse reactions during treatment.Conclusion Cistanche decoction combined with lactulose oral solution for constipation -irritable bowel syndrome patients has significant effect ,and can help to improve the quality of life of patients.