Evaluation effect of hydrochloric acid ammonium bromide cable auxiliary for the treatment of acute exacerbation of chronic bronchitis / 中国基层医药

ABSTRACT

Objective To observe clinical effect of the hydrochloric acid ammonium bromide auxiliary treatment of acute exacerbation of chronic bronchitis.Methods From February 2014 to January 2016,60 patients with chronic bronchitis in the Second People's Hospital of Yuyao were selected as observation objects.They were randomly divided into control group(30 cases)and observation group(30 cases)by using digital table method.The control group was treated with amoxicillin on the basis of conventional treatment, the observation group was treated with hydrochloric acid ammonia bromine based on the control group.The symptoms integral, clinical curative effect,blood gas analysis and lung function index were observed between the two groups.Results After treatment, cough,sputum, asthma of the observation group were(0.87 ± 0.32)points,(0.85 ± 0.34)points,(0.86 ± 0.34)points,respectively ,which were lower than those of the control group[(1.78 ± 0.48)points,(1.80 ± 0.47)points,(1.82 ± 0.46)points], the differences between the two groups had statisticallly significant(t =8.40,8.97,9.19, all P ＜0.05);The forced expiratory volume in one second(FEV1), forced expiratory volume in one second(FEV1/FVC)and forced vital capacity ratio in the observation group were(2 344.51 ± 373.44)mL,(69.34 ± 7.56)％,respectively,which in the control group were(2 001.63 ± 368.61)mL,(53.98 ± 6.78)％, respectively, the differences were statistically significant between the two groups(t =3.58,8.28, all P ＜ 0.05);The arterial oxygen partial pressure(PaO2)and artery CO2 partial pressure(PaCO2)in the observation group were(73.58 ± 6.33)mmHg,(43.51 ± 6.24)mmHg, respectively, which in the control group were(66.87 ± 7.25)mmHg,(51.05 ±6.36)mmHg, respectively, differences betwee.n the two groups were statistically significant(t =3.82,4.64, all P ＜0.05);The total effective rate in the observation group was 96.67％ ,which was higher than 66.67％ of the control group(x2 =10.42, P ＜ 0.01).Condusion Hydrochloric acid ammonia bromine adjuvant therapy for patients with acute exacerbation of chronic bronchitis can improve arterial blood gas analysis and pulmonary function indexes,alleviate clinical symptoms and improve clinical efficacy.