Correlation between platelet related parameters and acute rejection in renal transplant recipients / 中国基层医药

ABSTRACT

Objective To investigate the relationship between primary platelet parameters and early acute rejection (AR) after renal transplantation.Methods From October 2015 to June 2017,112 patients with renal failure underwent allograft renal transplantation in the Second People's Hospital of Shanxi Province were selected as the research objects,according to the preoperative and postoperative 30d in platelet parameters based on the occurrence of AR they were classified into the observation group (23 cases),no rejection for the control group (89 cases),analysis the difference of two groups of patients with platelet parameters [peripheral blood platelet count (PLT),platelet hematocrit (PCT),mean platelet volume (MPV) and platelet volume distribution width (PDW),the ratio of large platelet (P-LCR)] at preoperative (T0),postoperative 5 d (T1),10 d (T2) after operation,postoperative 15 d (T3) 15,30 d (T4).The correlation between PLT,PCT,MPV,PDW,P-LCR and acute rejection after renal transplantation was also analyzed.Results Compared with those of preoperative,the PLT [(122.06 ± 49.67) × 109/L vs.(185.26 ± 63.49) × 109/L)],PCT[(0.46 ± 0.28) ％ vs.(0.34 ± 0.06) ％)] in T1,T2 of the two group after surgery declined (P ＜ 0.05).MPV,PDW and P-LCR were increased in both groups after surgery (P ＜0.05),and the observation group were higher than that in the control group MPV[(13.69 ± 0.59) vs.(12.24 ±0.42),(16.08 ±0.61) vs.(12.52 ±0.57)],PDW[(13.26 ± 1.19) vs.(12.13 ±2.14),(15.46±3.15) vs.(12.72 ±2.09)],P-LCR[(30.57 ±7.29) vs.(28.13 ±6.34),(33.01 ±3.98) vs.(29.13 ± 6.91)] at the baseline of T1 and T2 (all P ＜ 0.05).Correlation analysis showed that the level of MPV,PDW,P-LCR and the occurrence of acute rejection after kidney transplantation were positively correlated (r =0.464,0.606,0.512,all P ＜0.05),while the PLT,PCT has nothing to do with the occurrence of acute rejection after kidney transplantation.Conclusion MPV,PDW and P-LCR can indirectly reflect the occurrence of AR after renal transplantation,and the trend of monitoring the three indexes of MPV,PDW and P-LCR after operation is an auxiliary diagnostic method for postoperative AR.