Clinical observation of amiodarone in the treatment of 66 patients with tachyarrhythmia / 中国基层医药

ABSTRACT

Objective To observe the clinical effect of amiodarone in the treatment of tachyarrhythmia . Methods From May 2016 to May 2017,66 patients with tachyarrhythmia in the First People's Hospital of Tongxiang were enrolled in the research .All patients were treated with amiodarone .The changes of blood pressure ,heart rate and electrocardiogram were observed before and after treatment ,and the clinical curative effect and adverse reaction were compared.Results The total effective rate was 81.82%(54/66),and the ineffective rate was 18.18%(12/66). After treatment,the systolic blood pressure,diastolic blood pressure and heart rate were (95.81 ±12.08) mmHg, (69.66 ±8.78)mmHg and (87.39 ±16.22)beats/min,respectively,which were significantly lower than those before treatment[(140.47 ±11.02)mmHg,(86.53 ±10.42) mmHg,(148.01 ±28.11)beats/min](t＝22.19,10.06, 15.18,all P＜0.01).After treatment,the PR interval and QT interval [(154.92 ±17.31)ms,(41.33 ±9.18)ms] were significantly prolonged compared with those before treatment [(138.61 ±12.87)ms,(36.44 ±8.57)ms] (t＝6.14,3.16,all P＜0.01).Adverse reactions occurred in 5 patients,and the incidence rate of adverse reactions was 7.58%.Conclusion The clinical efficacy of amiodarone in the treatment of patients with tachyarrhythmia is notable with rapid onset and high safety ,and it is worthy of clinical application .