Research progress of combined statins and clopidogrel on atherosclerotic plaques / 中国基层医药

ABSTRACT

Statins and antiplatelet drugs are the two cornerstones for the treatment of cerebrovascular disea －ses.This two drugs play a vital role in reducing platelet reactivity and inhibiting inflammation .Statins can effectively delay the progression of atherosclerosis ,reduce plaque volume and reduce the incidence of cerebrovascular diseases through multiple pathways .Clopidogrel is currently used primarily for anti －platelet aggregation .Some studies indicate that clopidogrel is also involved in the process of atherosclerosis ,but the mechanism is not clear .The anti－atheroscle－rosis effect of clopidogrel is often neglected , when statins are combined with clopidogrel .This article reviews the progress in the treatment of atherosclerotic plaque by statin combined with clopidogrel .