Effect of ticagrelor on acute coronary syndrome after percutaneous coronary intervention / 局解手术学杂志

ABSTRACT

Objective To compare the clinical efficacy of ticagrelor versus clopidogrel on the vessels without percutaneous coronary intervention(PCI),the cardiac structure and cardiac function in patients with acute coronary syndrome(ACS).Methods The clinical data of 95 patients with ACS who received PCI in southwest hospital from January 2014 to December 2016 were analyzed retrospectively,who were divided into two groups,47 patients in the treatment group with ticagrelor and 48 patients in the treatment group with clopidogrel.The average follow-up results of vessels without PCI,the changes of cardiac structure,cardiac function between two groups were compared.Results The follow-up results at 1 years after PCI showed that the revascularization rate 6.4％ of the vascular without PCI in ticagrelor group was significantly lower than 12.5％ of clopidogrel group(P ＜ 0.000 1);vascular disease progression and recurrence rate of angina in ticagrelor group was significantly lower than those of clopidogrel group;the LEVF and LVEDD of ticagrelor group improved better,and level of BNP was significantly decreased.There was no significant difference in risk of hemorrhage between two groups,but the incidence of dyspnea in ticagrelor group was higher than that of clopidogrel group.Conclusion Ticagrelor is superior to clopidogrel in the protection of vessels without PCI,and be helpful to improve the cardiac structure and cardiac function in patients with acute coronary syndrome(ACS) after PCI.