Correlation of dynamic contrast-enhanced MRI parameters and biomarkers in breast carcinoma / 中国介入影像与治疗学

ABSTRACT

Objective To investigate the correlation of quantitative parameters (volume transfer constant [Ktrans],rate constant [Kep]) derived from dynamic contrast-enhanced MRI (DCE-MRI) and biomarkers of estrogen receptor (ER),progesterone receptor (PR),human epidermal growth factor receptor-2 (HER-2),Ki-67 in breast carcinoma patients.Methods Data of immunohistochemistry and pharmacokinetic parameters of 100 patients with breast carcinoma were retrospectively analyzed.The values of Ktrans,Kep among the different intensity of ER,PR,HER-2 and Ki-67 expression were compared,and the relationships were analyzed.Results No significant difference of Ktrans,Kep was found among differentintensity of ER in breast carcinoma patients (P＞0.05),whereas no obvious correlation of Ktrans,Kep with ER expression was noticed (P＞0.05).Ktrans,Kep had statistical differences among different intensity of PR,HER-2,Ki-67 expression in breast carcinoma patients (P＜0.05),and the values of Ktrans,Kep were positively correlated with PR,Ki-67 expression (P＜0.05).Conclusion The values of Ktrans,Kep were positively correlated with the intensity of PR,Ki-67 expression in breast carcinoma patients,which might provide helpful tissue characterization information.