Relationship of CEUS quantitative parameters and enhance patterns with therapeutic effect of high-intensity focused ultrasound for hysteromyoma / 中国介入影像与治疗学

ABSTRACT

Objective To observe the relationship of efficacy of high-intensity focused ultrasound (HIFU) in treatment of hysteromyoma and quantitative parameters and enhance manifestations of CEUS.Methods Forty patients with single hysteromyoma underwent CEUS before HIFU,immediately after and 6 months after treatment,respectively.Time to peak (TTP),peak intensity (PI) of time-intensity curve were analyzed,and the enhance manifestations were observed.The ablation ratio of hysteromyoma immediately after HIFU and the ratio of reduction volume 6 months after treatment were also analyzed.Results Among 40 hysteromyomas,21 evenly enhanced (even enhance group) and 19 unevenly enhanced (uneven enhance group).The ablation rate greater than or equal to 80 ％ were observed in 22 hysteromyomas (ablation rate ≥80％ group),while ablation rate less than 80％ were observed in 18 lesions (ablation rate ＜80％ group).There were significant differences of TTP ([27.48 ± 7.89] s vs [21.78 ± 4.76] s;t =2.69,P =0.01),PI ([44.29 ± 3.74] dB vs [47.39±4.68]dB;t=-2.34,P=0.02) and the ratio of reduction volume 6 months after HIFU ([59.47±16.21]％ vs [37.30±11.89]％;t=4.83,P＜0.01) between ablation rate ≥80％ group and ablation rate ＜80％ group.The ablation rate ([65.03±18.39]％ vs [41.64±18.78]％;t=-4.49,P＜0.01) and the ratio of reduction volume 6 months after HIFU ([84.74±7.76]％ vs [58.18±12.94]％;t=-3.21,P＜0.01) were significantly different between even enhance group and uneven enhance group.TTP and the ratio of reduction volume 6 months after HIFU positively correlated with the ablation rate (r =0.448,0.660,both P＜ 0.01),while PI and enhance manifestations negatively correlated with ablation rate (r =-0.460,rs =-0.614,both P＜ 0.01).Conclusion TTP,PI of time-intensity curve and enhance patterns of hysteromyoma correlated with the ablation rate of HIFU,which having certain clinical value in evaluation of therapeutic efficacy.