Effects of aerobic exercise on the food intake of obesity rats and obesity resistant rats by regulating the expression of ghrelin in stomach / 中国康复医学杂志

ABSTRACT

Objective:To explore the effect of aerobic exercise on the food intake of obesity rats and obesity resistant rats and some mechanisms Method:The four years old Sprague-Dawley rats were randomly divided into standard chow group (C) and high-fat diet group.After 10 weeks feeding,the obese group (OB group) and obesity resistant group (OR group) induced by high-fat diet were screened out.Then all the rats in OB group and OR group were respectively and randomly divided into exercise rats (OB-Sw group,OR-Sw group) and non-exercise rats (OB-Sed group,OR-Sed group).Aerobic swimming exercise for the exercise rats was defined as 60％ of individual exhaustion exercise intensity,45 minutes per day,5 times per week.Meanwhile,the body weight and food intake of the exercise and non-exercise rats were monitored every week.After 8 weeks intervention,the serum and gastric tissue of rats were obtained,and then the TG,TC,LDL-c,HDL-c in serum and the expression of ghrelin in gastric tissue were detected.Result:Ten weeks later,the body weight of the rats with high-fat diet showed a significant difference compared with the rats with standard chow group (P ＜ 0.05).The content of LDL in OB-Sed group was significantly higher than that in C group (P＜0.05).After 8 weeks aerobic exercise,for the food intake,OB-Sed group was higher than OB-Sw group and OR-Sed group was higher than OB-Sw group.The expression of ghrelin in gastric tissue in OB-Sed group and OR-Sed group was higher than that in OB-Sw group,OB-Sw group and C group.Conclusion:Exercise might reduce the food intake of obesity rats and obesity resistant rats by reducing the expression of ghrelin in stomach.