Surveillance of antimicrobial resistance in the clinical isolates from Children's Hospital of Chuzhou during the period from 2014 to 2016 / 中国感染与化疗杂志

ABSTRACT

Objective To investigate the distribution and antibiotic resistance of bacterial isolates from Children's Hospital of Chuzhou during the period from January 2014 through December 2016.Methods A retrospective analysis was carried out for 1 057 bacterial strains isolated from clinical specimens from January 2014 through December 2016.Results Of the 1 057 clinical isolates collected,gram positive organisms and gram-negative organisms accounted for 45.3％ (479/1 057) and 54.7％ (578/1 057),respectively.The top 5 most frequently isolated microorganisms were E.coli (19.6％),S.aureus (15.9％),Klebsiella spp.(14.4％),coagulase negative Staphylococcus (12.6％) and S.pneumoniae (9.1％).All the S.pneumoniae isolates were susceptible to penicillin.Prevalence of MRSA was 29.8％ among S.aureus and the prevalence of MRCNS was 74.4％ in CNS.All Staphylococcus strains were susceptible to daptomycin,linezolid and vancomycin.E.faecium strains showed much higher resistance rate to most of the antimicrobial agents tested than E.faecalis.The prevalence of ESBLs-positive strains was 50.2％ in E.coli,32.4％ in Klebsiella spp.(K.pneumoniae and K.oxytoca) and 83.3％ in P.mirabilis,respectively.The Enterobacteriaceae strains were highly sensitive to carbapenems.A total of 12 (2.5％) carbapenem-resistant strains were identified from 485 Enterobacteriaceae isolates.P aeruginosa and Acinetobacter spp.were highly sensitive to carbapenems.Conclusion Gram negative bacteria are still dominant pathogens in clinical practice.It is necessary to strengthen monitoring of antibiotic resistance,which is still a serious issue of great concern.