Distribution of interleukin 17 receptor mRNA in rhesus macaques / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 19-24, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-702666
ABSTRACT
Objective:
To delineate the distribution and abundance of interleukin 17 receptor mRNA in normal tissues of rhesus macaques.Methods:
Tissue samples were collected from different systems including lymphoid system,digestive system and genital system and the mRNA levels of IL-17RA and IL-17RC were examined by real time RT-PCR.Meanwhile the levels of IL-17RA and IL-17RC mRNA in the PBMCs of rhesus macaques,African green monkeys and cynomolgus monkeys were examined.Results:
IL-17RA mRNA was expressed in all the tested tissues and the levels were significantly different among these systems (P<0.05).IL-17RC mRNA level in the large intestine was higher than that in the small intestine.IL-17RA mRNA level in rhesus macaque PBMCs was 3 and 5 times higher than that of cynomolgus monkeys and African green monkeys respectively,while IL-17RC mRNA in the PBMCs was below the limit of detection.Conclusion:
IL-17RA is widely distributed in rhesus macaques;the expression level is different among different tissues and species.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2018
Type:
Article
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