Research progress on role of macrophages in tumor immunotherapy / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 277-281,286, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-702717
ABSTRACT
Objective:
Accumulating evidences prove that macrophages affect tumor initiation and prognosis. Especially,tumor-associated macrophages (TAMs) are considered to enhance tumor growth,progression,angiogenesis,invasion and metastasis. Furthermore,tumor suppressive microenvironment can " reeducate" and polarize the phenotype and function of TAM. Recently, researchers use different ways to interfere and modify the phenotype and function of macrophages,to improve the recognition, phagocytosis and antigen presentation of macrophage,and enhance its antitumor activity. We will discuss the pro-tumorigenic properties of macrophage and TAM-targeting therapy as a promising novel strategy for tumor immunotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS