Effects of recombinant human erythropoietin and β-aescin on functional recovery and secondary injury of nerve cells in rats after spinal cord injury / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 589-594, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-702779
ABSTRACT
Objective:
To study the effect of recombinant human erythropoietin and β-aescin on functional recovery and secondary injury of nerve cells in rats after spinal cord injury.Methods:
A total of 50 female SD rats were randomly divided into five groups according to their injury and treatment.The rats in the rh-EPO group were treated with recombinant human erythropoietin,and the β-SE group was treated with β-aescin,and the combination group was treated with recombinant human erythropoietin and the treatment of β-aescin,compared the indicators.Results:
The BBB motor function scores of the combination therapy group were significantly higher than those of rh-EPO group,β-SE group and injury group.The neurological function of the combined treatment group was better than that of rh-EPO group and β-SE group(P<0.05).The content of Mg2+in the combination group was significantly higher than that in the rhEPO group and the β-SE group,and the difference was significant (P<0.05).Conclusion:
The combination of re-combinant human erythropoietin and β-aescin can help improve the BBB motor function score,promote the recovery of motor function and delay the development of secondary injury of nerve cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2018
Type:
Article
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