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Seroconversion in Nonresponders to Hepatitis B vaccination after double dose vaccination only once
Journal of the Korean Academy of Family Medicine ; : 1461-1468, 1997.
Article in Korean | WPRIM | ID: wpr-70280
ABSTRACT

BACKGROUND:

Korea is, known to be an endemic area of viral hepatitis B, and 5-6% of population are carriers. Immunization can reduce the spread of hepatitis B infection. Hower, not all people respond to hepatitis B immunsation. 5-15% of primary vaccinees fail to be immunized. After revaccination, only 37.5 44% of the primary failures elicit antibody response. Recent studies have reported that it is effective to inject a double dose vaccination in immunocompromsed patients. In some country, they recommend that neonate whode mother is HBV carrier shoud receive double dose vaccination. This study documented the results of double dose vaccintion only once to nonrsponders toward the HBV immunzation.

METHODS:

Healthy nonresponders to Hepatitis B immunization were recuited from Sep. 1995 to Aug. 1996. Subjects with their AST/ALT level over 40, or over 65 years old were excluded. They were received 2ml of plasma-derived vaccine(Hepavax-B) intramuscularly in the deltoid muscle. Anti-HBs antibody testing were performed at 1 to 3 months after vaccintion.

RESULTS:

17 healthy nanreponders to Hepatitis B immunization(male 10, female 7) were included. Their mean ages were 47(32 to64), AST/ALT level 20/19(16 to 28/11 to 35), smoking 4.3pys(1 to 7). Seroconversion occured in 13 of them(76.5%).

CONCLUSIONS:

Nonresponders to Hepatitis B vaccintion respond well to double dose vaccination once.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Smoke / Smoking / Immunization, Secondary / Immunization / Vaccination / Deltoid Muscle / Hepatitis / Hepatitis B / Korea / Mothers Limits: Aged / Female / Humans / Infant, Newborn Country/Region as subject: Asia Language: Korean Journal: Journal of the Korean Academy of Family Medicine Year: 1997 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Smoke / Smoking / Immunization, Secondary / Immunization / Vaccination / Deltoid Muscle / Hepatitis / Hepatitis B / Korea / Mothers Limits: Aged / Female / Humans / Infant, Newborn Country/Region as subject: Asia Language: Korean Journal: Journal of the Korean Academy of Family Medicine Year: 1997 Type: Article