Effect of inflammatory factor and neurotransmitter of Yizhi Xingnao Fang combined with western medicine for patients with alzheimer's disease / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 699-702, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-702800
ABSTRACT
Objective:
To study the effect of inflammatory factor and neurotransmitter of Yizhi Xingnao Fang combined with western medicine for patients with alzheimer's disease.Methods:
124 cases alzheimer's patients from October 2014 to October 2016 were divided into observation group and control group,the control group given donepezil etc conventional western medicine therapy,ob-servation group given Yizhi Xingnao Fang combinde with western medicine therapy. 12 weeks after treatment,cerebrospinal fluid in-flammatory factors,neurotransmitter and clinical efficacy were compared between two groups.Results:
Observation group effective rate 80.65% was significantly higher than control group 64.52% (X2= 4.052 9,P<0.05);cerebrospinal fluid TNF-α,IL-6 were significantly lower than control group,IL-4,IL-10 were significantly higher than control group (t=10.911,8.739,5.000,4.046,P<0.05,P<0.01);DA,5-HT,NE were significantly higher than control group(t=9.435,7.916,5.985,P<0.05,P<0.01).Conclusion:
Yizhi Xingnao Fang combined with western medicine therapy help to improve the clinical symptoms and therapeutic effect,which may be related to the suppression of inflammatory symptoms,regulation of neurotransmitter expression level.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2018
Type:
Article
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