Research progress of microRNAs on development and function regulation of macrophages / 中国免疫学杂志

ABSTRACT

MicroRNAs (miRNAs) are a kind of non-coding single stranded RNAs molecules formed with length of 18-25 nt, which play an important role in the maturation,development,proliferation,differentiation and activation of immune cells,as well as antibody production,immune response and release of inflammatory mediators.Macrophages are members of the innate immune system and also involved in the initiation and effector processes of adaptive immune responses.MiRNAs have drawn a lot of attention to the bio-logical processes in development,activation,differentiation and senescence of macrophage.In this paper,the influences of miRNAs in development,polarization,function and apoptosis of macrophages,and macrophage-related diseases were reviewed in order to provide theoretical references for the related research of miRNAs and macrophages.