A Clinicopathologic Study of Immature Teratoma of the Ovary / 대한산부인과학회잡지

ABSTRACT

OBJECTIVE: In this retrospective study, we analyzed the clinical and pathological characteristics of immature teratoma of the ovary. METHODS: Between 1990 and 2003, 26 patients with immature teratoma of the ovary treated in the Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea were identified, and reviewed retrospectively for patient profiles, International Federation of Gynecologists and Obstetricians (FIGO) disease stage, mode of therapy, and length of survival. RESULTS: The mean and median age at diagnosis was 27.0 and 25.5 years (range 11-58 years), respectively. Tumors were 73.1% (19/26) stage I, 3.8% (1/26) stage II, 19.2% (5/26) stage III, and 3.8% (1/26) stage IV. Eighteen patients (69.2%) had pathologic grade 2 or 3. Twenty of 26 patients underwent the conservative surgery including unilateral salpingo-oophorectomy, unilateral oophorectomy or cystectomy, and other patients were performed the total abdominal hysterectomy with bilateral salpingo-oophorectomy. All except five patients received adjuvant combination chemotherapy. Second look operation following combination chemotherapy was done in nine cases. Two patients who had grade III tumors died. Follow-up was available for all the patients, with a mean duration of 43.9 months. No recurrence was observed during this period. CONCLUSION: Immature teratoma of the ovary is a potentially curable disease in today's practice. Low stage and low grade tumors have an excellent prognosis and conservative surgery and preservation of fertility is warranted in those cases.