Correlation analysis between intracranial pressure and MMP-9 in blood serum after primary intracerebral hemorrhage after hematoma removal / 中国脑血管病杂志

ABSTRACT

Objective To investigate the correlation between serum matrix metalloproteinase-9 (MMP-9) and intracranial pressure after hematoma removal in patients with primary intracerebral hemorrhage (PICH). Methods From January 2015 to June 2017,72 consecutive patients with PICH treated with removal of hematoma + intracranial pressure probe implantation at the Department of Neurosurgery, the Second Affiliated Hospital of Xinjiang Medical University were enrolled retrospectively. They were divided into 3 groupsgroup A (n=25,intracranial pressure ≤10 mmHg);group B (n=24,intracranial pressure 11-20 mmHg),and group C (n=23,intracranial pressure >20 mmHg) according to the maximum value of monitoring intracranial pressure. The serum MMP-9 levels of all patients were detected using ELISA at 1, 3,5,7 and 14 d after procedure,the volume of cerebral edema was monitored by head CT,and intracranial pressure was continuously observed for 7 d after procedure using the intracranial pressure monitor. Results At 1,3,5,7,and 14 d after removal of the hematomas,the MMP-9 levels in group A were 82 ± 11,117 ± 12,156 ± 14,132 ± 14,and 108 ± 18 mg/L,respectively,and the volumes of brain edema were 15 ± 6,19 ± 7,22 ± 8,19 ± 7,and 17 ± 6 cm3 ,respectively. The MMP-9 levels in group B were 93 ± 14,138 ±13,188 ± 17,153 ± 17,and 134 ± 12 mg/L,respectively,and the volumes of brain edema were 19 ± 7,23 ± 8,30 ± 10,26 ± 8,and 20 ± 7 cm3 ,respectively;the MMP-9 levels in group C were 104 ± 16,199 ± 14,390 ± 22,296 ± 15,and 213 ± 15 mg/L,respectively,and the volume of brain edema were 22 ± 8,30 ± 10,42 ± 12,32 ±19,and 24 ±8 cm3,respectively. There was significant difference between groups (P<0. 05),and there was a moderate positive correlation between the changes of MMP-9 level and the volume of intracranial cerebral edema (r =0. 62,P <0. 01). Conclusion After the removal of the hematomas of primary cerebral hemorrhage, the MMP-9 level in blood serum of the patients was positively correlated with the volume of brain edema,the higher the level of MMP-9,the higher the intracranial pressure.