Related factors for rapid eye movement sleep behavior disorder in early Parkinson disease / 中国神经精神疾病杂志

ABSTRACT

Objective To investigate the morbidity of rapid eye movement sleep behavior disorder(RBD) in early Parkinson disease (PD)and its related factors. Methods One hundred twenty-five early PD patients were divided into RBD group (n=51)and non-RBD group (n=74),according to the complicated with RBD.We collected the clinical data and used univariate and multivariate logistic regression methods to analyze the risk factors for rapid eye movement sleep behavior disorder in early Parkinson disease. Results The incidence of RBD is 40.80% in early PD patients.Univariate analysis showed that the age, the motor phenotype (akinetic-rigid-type), modified Hoehn-Yahr(H-Y)grade, freezing, constipation and restless leg syndrome (RLS)were significantly higher in RBD group than in non-RBD group (P<0.05). Multivariate logistic regression revealed that constipation ( P=0.001,95% CI1.980~12.253,OR=12.912)and RLS (P=0.014, 95% CI 1.322~12.015, OR=6.378 ) were independent influencing factors for RBD in early PD patients. Conclusion Early PD patients with constipation or RLS are prone to RBD.