Phagocytic function of microglia and underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases / 中国比较医学杂志
Chinese Journal of Comparative Medicine
;
(6): 120-126,102, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-703330
ABSTRACT
Microglia, a type of neuroglia, has a variety of functions such as phagocytosis, clearance, antigen presentation,promotion of repairment of injury and secretion of extracellular signaling molecules,in which phagocytosis of microglia plays a crucial role in maintaining brain tissue,remodeling synapses,clearance of several aberrant proteins such as amyloid β in neurodegenerative diseases, and in neurodevelopment. This review briefly summarizes the phagocytic function of microglia with underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases,aiming to provide a new thought for the therapy of neurodegenerative diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Comparative Medicine
Year:
2018
Type:
Article
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