Relationship between sLR11 level,type 2 diabetes and carotid CIMT / 中国糖尿病杂志

ABSTRACT

Objective To investigate the relationship and clinical significance between circulating soluble low-density lipoprotein receptor family member 11 (sLR11) level,type 2 diabetes (T2DM) and carotid intima-media thickness (CIMT). Methods Newly diagnosed patients with T2DM (T2DM group,n=55)and healthy controls (NC group,n=55)were enrolled in this study. The sLR11 level was measured by ELISA. The level of sLR11,CIMT,age,blood lipid,and blood pressure were compared between the two groups. Another 165 patients with T2DM treated with conventional pharmaceutical medications were also selected in this study. The relationship between sLR11,CIMT and atherosclerosis were analyzed. The influences of sLR11 and FPG in the progress of CIMT were also evaluated. Results The sLR11 level and CIMT were higher in T2DM group than in NC group [(8.35 ± 2.65) vs (6.64 ± 1.99)ng/ml,P= 0.026;(0.87 ± 0.37) vs (0.73 ± 0.26) mm,P= 0.037]. In the 165 patients with T2DM,the level of sLR11 and CIM T were(9.79 ± 3.54)ng/ml and (0.79 ± 0.18)mm respectively. Correlation analysis showed that sLR11 levels were positively correlated with age,systolic blood pressure, LDL-C,fasting plasma-glucose (FPG),and HbA1c (r = 0.226,0.162,0.166,0.276,0.176). Multivariate linear regression analysis indicated that FPG was an independent risk factor for sLR 11 (β=0.175,P<0.05),and sLR11 was a independent risk factor of CIMT in the absence of age factor (β=0.008,P<0.05). Conclusion The sLR11 level may relate to blood glucose in T 2DM,and reflect the situation of CIM T and the pathological status of vessel intimal smooth muscle cells (SMCs).