Pivotal role of cell hyperactivation in the pathogenesis of different diseases and its mechanism / 中华危重病急救医学

ABSTRACT

Inflammasomes are key inflammatory signaling platforms that detect several stimulus derived from microbial substances and sterile environmental insults, eliciting pyroptosis and the release of cytokines. Recent studies have found that inflammasomes could also elicit cell hyperactivation which is defined as living cells that release interleukin-1 (IL-1). Hyperactive cells promote long-term IL-1 release and then activate adaptive immune response, which has a pivotal role in the infection ofSalmonella andStaphylococcus aureus, as well as in non-lethal inflammatory sepsis. So it is of great significance to explore the pathogenesis of cell hyperactivation in several inflammatory diseases. Here, we summarized the possible pathogenesis of cell hyperactivation in different inflammatory diseases, such as infection, sepsis and acute respiratory distress syndrome (ARDS), providing a theoretical basis for clinical treatment of these diseases.