Relationship between serum fibulin-3 level and clinicopathological factors in patients with colon cancer / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
;
(4): 767-769, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-703763
ABSTRACT
Objective:
This study aimed to assess serum fibulin-3 levels in patients with colon cancer compared with healthy controls and its relationship to demographics and tumor pathology.Methods:
A total of 97 patients (mean age,59.6 years;57.7% males) with colon cancer and 86 controls (mean age,58.8 years;54.7% males) were included.Serum levels of fibulin-3 were determined using a commercially available sandwich ELISA (Enzyme-Linked ImmunoSorbent Assay).Results:
Preoperative serum fibulin-3 levels were significantly lower in the group of patients with colon cancer(39.86 ± 24.37) ng/mL compared with the control group (94.25 ± 31.28) ng/mL.Preoperative fibulin-3 levels and negatively correlated with the degree of tumor TNM stage (P<0.05),fibulin-3 levels gradually decreased by tumor stage from Ⅰ to Ⅳ and the difference is statistically significant.The serum fibulin-3 levels were correlated significantly with tumor size,lymph node metastasis,distant metastasis and CEA levels(P<0.05).Conclusion:
It was concluded that fibulin-3 is expressed at a lower level in colon cancer,and it is significant correlated with tumor burden,decreased level of fibulin-3 can serve as a marker for advanced colon cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS