Expression and clinical significance of TOPOⅡα,Ki-67 and p53 in triple negative breast cancer / 中国现代普通外科进展

ABSTRACT

Objective:To detect the expression and clinical significance of TOPO Ⅱ α 、Ki-67 and p53 in triple negative breast cancer (TNBC).Methods:The expression levels of TOPO Ⅱ α、Ki-67 and p53 were detected by IHC in 265 cases with invasive breast cancer.And analyze the relationship between the expressions and clinicopathoiogical features including tumor size,TNM stage,lymph node metastasis and histological grade.Results:Among 265 cases of breast cancer patients,TNBC patients accounted for 15.47％ (n=41),non-TNBC accounted for 84.53％ (n=224).the high expression rate of TOPO Ⅱ α,Ki-67 and p53 in TNBC were 78.05％,73.17％,and 65.85％,respectively,the difference was statistically significant compared with non-TNBC group (P＜0.05).The high expression of TOPO Ⅱ α was correlated with tumor volume,histological grading(P＜0.05);and the high expression of p53 was associated with histological grade,lymph node metastasis (P＜0.05);the high expression of Ki-67 was related with histological grade and tumor volume (P＜0.05).The expression of TOPO Ⅱ α,Ki-67 and p53 in TNBC was correlated.Conclusion:By detecting the expression of TOPO Ⅱ α,Ki-67 and p53,clinicians have a better understand of the biological behavior of TNBC,and provide an important basis for the selection of chemotherapy regimens.