Impact of High-salt Diet on Plasma Level of Vascular Endothelial Growth Factor C and Its Relationship to Blood Pressure in Healthy Subjects and Hypertension Patients / 中国循环杂志

ABSTRACT

Objectives: To investigate the impact of high-salt diet on plasma level of vascular endothelial growth factor C (VEGF-C) in healthy subjects and hypertension patients; to explore the relationship between VEGF-C level and blood pressure (BP). Methods: Our research included in 2 groups Essential hypertension (EH) group, 75 patients treated in our hospital from 2013 to 2014 and Control group, 98 healthy subjects at the same period. Using salt-intake 6 g/day as the borderline, both groups were respectively divided into High-sodium diet (HS) subgroups and Low-sodium diet (LS) subgroups. The age, gender, creatinine clearance (CCr), UA, fast blood glucose (FBG), body mass index (BMI), blood lipids (TC, TG, HDL-C, LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), heart rate (HR) and CF-PWV were compared between EH group and Control group, HS subgroups and LS subgroups. Results: Compared with Control group, EH group had increased plasma level of VEGF-C, (3 940.8±1 141.1) pg/ml vs (2 938.0±987.0) pg/ml, P<0.001; the age, BMI, SPB, DBP, PP, MAP and CF-PWV were different between 2 group, all P<0.005. In ES group, compared with LS subgroup, HS subgroup showed the higher VEGF-C (4 208.8±113.1) pg/ml vs (3 515.8±1 070.1) pg/ml, P=0.009; the age, SBP, DBP and PP were different between 2 group, all P<0.005. In Control group, compared with LS subgroup, HS subgroup showed the higher VEGF-C (3 158.7±917.2) pg/ml vs (2 655.7±1 011.3) pg/ml, P=0.012; the age BMI and CCr were different between 2 group, all P<0.005, while BP was similar between 2 subgroups. Spearman correlation study presented that with adjusted confounding factors, no matter in all participates and in EH group or Control group, MAP were positively related to plasma levels of VEGF-C (r=0.536, P<0.001 and r=0.546, P=0.002 or r=0.291, P=0.006) respectively. Conclusions: High-sodium diet could increase plasma VEGF-C level in either healthy subjects or hypertension patients, VEGF-C level was positively related to BP.