The role of microRNA-137 gene in schizophrenia / 中华行为医学与脑科学杂志

ABSTRACT

Schizophrenia is a chronic devastating psychiatric disorder,which severely damages pub-lic mental health. The pathophysiological mechanism of schizophrenia is complex and the etiology of schizo-phrenia is still unclear. Epidemiological study,twins study and family study show that genetic factors play a substantial part in the process of schizophrenia. Previous research indicates that there is a close association between microRNA-137 and schizophrenia,and that the ablation of microRNA-137 significantly affects clini-cal symptoms and prognosis of patients with schizophrenia. So it highlights the relationship between microR-NA-137 and schizophrenia,which reveals its special role in the etiological mechanism of schizophrenia,and may provides new perspective about the treatment of patients in schizophrenia.