P300 for the assessment of cognitive disorders in Chinese patients with Parkinson's disease: a Meta-analysis / 中华行为医学与脑科学杂志

ABSTRACT

Objective To assess the clinical utility of P300 for the assessment of cognitive disorders in Chinese patients with Parkinson's disease (PD) by meta-analysis.Methods Studies comparing the P300 between PD patients with different cognitive disorders (dementia,mild cognitive impairment (MCI),and no cognitive impairment;the former two were “cognitive impairments”,while the latter two were “nondementia”) and healthy controls were retrieved by searching within major Chinese and English databases.Studies,whose case and control groups were matched for age and gender,were rated as high quality.Weighted mean differences (WMDs) in P300 latency and amplitude between groups were calculated by using meta-analysis.Results In total,23 studies were included and 20 of which were rated high quality.Demented PD patients had statistically significant longer P300 latency (WMD56.14,95％ CI19.06,93.23) and lower amplitude (WMD-1.30,95％CI-2.08,-0.51) than non-demented PD patients.PD patients with MCI had statistically significant longer P300 latency (WMD13.71,95％CI5.13,22.29) and lower amplitude (WMD-1.25,95 ％ CI-2.29,-0.21) than PD patients without cognitive disorders.However,no significant differences in P300 latency (WMD4.16,95％ CI-13.85,22.17) and amplitude (WMD0.23,95％ CI-1.72,2.17) were found between PD patients with dementia and MCI.Conclusion Among Chinese PD patients,there are significant P300 differences between those with dementia and without dementia,and between MCI and those without cognitive impairments,however,but no significant P300 differences between those with dementia and MCI.