The association of serum levels of MIF and EGF and cognitive function in first-episode schizophrenic patients / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore the serum levels of macrophage migration inhibitory factor(MIF)and epidermal growth factor(EGF) in first-episode schizophrenia patients characterized and the correlation of MIF,EGF serum levels with psychotic symptoms and cognitive function.Methods The serum levels of MIF and EGF in patients (53 cases) and controls (58 cases) were measured by enzyme-linked immunosorbent assay (ELISA).The patients' psychotic symptoms were assessed by positive and negative syndrome scale (PANSS).The MATRICS consensus cognitive battery (MCCB) was used to assess the cognitive function.Results MIF serum level in cases group was higher than that of control group and the difference was statistically significant((50.54±23.05)μg/L vs (36.72± 18.52) μg/L) (P＜0.01).EGF serum level in cases group was higher than that of control group and the difference was statistically significant((5 163.40±2 289.76) vs (3 584.83± 1 444.71) ug/L) (P＜0.01).There was a positive correlation between serum MIF level and PANSS score in schizophrenic patients(P＜0.05).Score of TMT in MCCB in cases group was significantly higher than that in control group (P＜0.01),while scores of BACS SC,HVLT-R,BVMT-R and CF in MCCB in cases group was significantly lower than those in control group (P＜0.01).Serum level of MIF in cases group was significantly positively correlated with score of BVMT-R(P＜0.05),and serum level of EGF in cases group was significantly positively correlated with score of BVMT-R (P＜ 0.05).There was a positive correlation between serum MIF levels and serum EGF levels in the cases group (P＜0.05).There was a positive correlation between serum MIF and serum EGF levels in the control group (P＜0.05).Conclusion The clinical symptoms and partial cognitive impairment in patients with first-episode schizophrenia are related to the concentration of serum protein factors,and there are neuroimmunological abnormalities and neurotrophic imbalances and they are related.